Restricted T cell receptor repertoire in CLL-like monoclonal B cell lymphocytosis and early stage CLL
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چکیده
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)–like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring
In the revised National Cancer Institute Working Group (NCI-WG)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) guidelines for CLL, CLLlike monoclonal B lymphocytosis (MBL) is defined as the presence of less than 5 109/L B lymphocytes in the peripheral blood. However, the concentration of MBL in the blood is extremely variable. MBL in subjects with lymphocytosis require treatment...
متن کاملMonoclonal B-cell lymphocytosis: recommendations from the Dutch Working Group on CLL for daily practice.
Monoclonal B-cell lymphocytosis (MBL) is defined by the presence of small B-cell clones in asymptomatic individuals. Usually, MBL cells are characterised by a chronic lymphocytic leukaemia (CLL) phenotype ('CLL phenotype MBL'); however, an atypical phenotype ('atypical-CLL phenotype MBL') or non-Hodgkin lymphoma phenotype ('non-CLL phenotype MBL') can be found as well. The prevalence of MBL in ...
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INTRODUCTION Molecular alterations leading progression of asymptomatic CLL-like high-count monoclonal B lymphocytosis (hiMBL) to chronic lymphocytic leukemia (CLL) remain poorly understood. Recently, genome-wide association studies have found 6p21.3, where the human leukocyte antigen (HLA) system is coded, to be a susceptibility risk region for CLL. Previous studies have produced discrepant res...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2018
ISSN: 2162-402X
DOI: 10.1080/2162402x.2018.1432328